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Linked Genes: Db, Ml & Pg

The pattern genes that travel together on chromosome 1

Most colour genes are inherited independently — each one is a separate coin-flip. But three of the pattern genes are an exception: Dark Brown (Db), Melanotic (Ml) and Pattern (Pg) sit close together on the same chromosome, so they are usually inherited as a set. That linkage is a big part of why a pattern like mille fleur holds together, and it is built into how the Breeding Outcomes tool calculates a cross. For the wider system, see the Genetics Guide.

The three genes

Each of the three does a different job in building a pattern — for what they do, see the pattern genes page. This page is about how they inherit.

GeneWhat it contributes
Dark Brown (Db)Deepens and shifts the gold/red ground colour.
Melanotic (Ml)Adds and extends black through the plumage.
Pattern (Pg)Organises the black into structured markings — lacing, spangling and the like.

Why linkage matters

Genes that sit close together on a chromosome do not assort independently — they travel together far more often than chance would allow. Db maps to the SOX10 region and Ml to the GJA5 region of chromosome 1, with Pg showing strong empirical linkage to both.1 Only an occasional crossover during meiosis reshuffles them:

PairEstimated recombination
DbMl~12%
MlPg~10%
DbPg~22%

In practice that means roughly 85% of a bird's gametes carry the parental combination of these three intact, where three unlinked genes would keep the same combination only about a quarter of the time.2 The trio behaves almost like a single unit.

In mille fleur

Mille fleur's genotype is eb/eb · Db/Db · Pg/Pg · Ml/Ml · mo/mo — and three of those five defining genes are exactly this linked group. Because Db, Pg and Ml ride together on chromosome 1, a mille fleur bird usually passes them on as a package rather than as three independent throws. That is a large part of why the pattern travels reliably through a line once it is fixed, and why related varieties — Tollbunt, porcelain — are built by swapping or adding a single gene around that same stable core.

How the Breeding tool handles it

The Breeding Outcomes tool marks Db, Ml and Pg with a small and, when a cross involves more than one of them, shows a linked-gene note. The individual Db/Ml/Pg Punnett squares each show their own locus at the standard Mendelian ratios — but the combined F1 Genotype Frequencies table further down applies the actual linked recombination ratios by default.2 So the frequencies you read off already account for the linkage, instead of pretending the three genes assort freely.

Try it. Open Gold Mille Fleur × Porcelain in the Breeding Outcomes tool and look for the on the Db/Ml/Pg rows and the linked-gene note above the squares. The F1 table itself won't show a numeric difference for this pair — both parents are homozygous at Db/Ml/Pg, so every F1 chick gets the same single genotype whether or not linkage is applied. To see linkage actually change the numbers, scroll to F2 Planning, select that F1 genotype, and click ♂ F1 × ♀ F1 Intercross. Now both parents are heterozygous at all three loci at once, so the toggle appears and does something: the parental-type class (Db/db+ · Pg/pg+ · Ml/ml+) comes out around 8% under real linkage versus about 3% if the three genes assorted independently, and the fully-homozygous-mutant class (Db/Db · Pg/Pg · Ml/Ml) — which looks like it should be a rare double recombinant — is actually about 4% under linkage versus well under 1% independent, because that combination is the intact, non-recombined haplotype inherited whole from the Porcelain parent.
References & notes
  1. Molecular mapping of the linked Db/Ml pattern loci on chromosome 1 (SOX10 / GJA5 regions): Schwochow, D., et al. (2021) Pigment Cell & Melanoma Research; Sandve, S. R., et al. (2021) PNAS. See the pattern genes references.
  2. The recombination-frequency estimates and the linked-ratio calculation are those used by the Breeding Outcomes tool, consistent with the chicken genetic map: International Chicken Genome Sequencing Consortium (2004) Nature 432:695–716.
Related: what the pattern genes do · mille fleur genetics · plan a cross